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Purification Techniques | Application of Gel Filtration Chromatography Resin in Viral Vaccines 27 2025.03
Purification Techniques | Application of Gel Filtration Chromatography Resin in Viral Vaccines
As a type of acellular organism, viruses typically parasitize living cells, utilizing the host's metabolic system to replicate and proliferate.Biological virus is a non-cellular life form characte...
Exploring the Invisible Bridge of Biopharmaceuticals — Pass-Through System 26 2025.03
Exploring the Invisible Bridge of Biopharmaceuticals — Pass-Through System
In the biopharmaceutical field, the cleanliness and safety of the production environment are directly linked to the quality of the pharmaceutical products. Today, let’s explore a critical technology ...
Overcoming CHO Cell Culture Challenges: Dissolved Oxygen Balance and Mass Transfer Optimization 25 2025.03
Overcoming CHO Cell Culture Challenges: Dissolved Oxygen Balance and Mass Transfer Optimization
Oxygen is essential for cellular respiration and plays a critical role in cell function.In cells, oxygen serves as the terminal electron acceptor in the electron transport chain, where it combines wit...
Sterile Water for Injection vs. Water for Injection: Comprehensive Analysis of Their Differences and Applications 24 2025.03
Sterile Water for Injection vs. Water for Injection: Comprehensive Analysis of Their Differences and Applications
In the pharmaceutical and medical fields, the quality of water for injection is directly linked to drug safety and patient health. Although Sterile Water for Injection (SWFI) and Water for Injection (...
From Selection to Application: Technical Matching Analysis of Agitators with Fluids of Different Viscosities 23 2025.03
From Selection to Application: Technical Matching Analysis of Agitators with Fluids of Different Viscosities
Stirring plays a crucial role in both experimental processes and industrial production. Its primary function is to ensure thorough contact and mixing of two or more different media or to facilitate c...
Total Solutions for Exosomes 13 2025.02
Total Solutions for Exosomes
Exosomes are small membrane-bound vesicles with a lipid bilayer structure, secreted by most cell types within the body. Their diameter typically ranges from approximately 30 to 150 nm.Exosomes are act...
Unlocking the Downstream Purification Process for Viral Vectors 12 2025.02
Unlocking the Downstream Purification Process for Viral Vectors
Viral vectors are commonly used tools in molecular biology, designed to deliver genetic material into cells, which can occur in live organisms or cell cultures. The principle behind this involves util...
Interpretation and Case Sharing of Resin Change for Marketed Drugs 11 2025.02
Interpretation and Case Sharing of Resin Change for Marketed Drugs
On January 13, 2021, the National Medical Products Administration (NMPA) released the Provisions for Post-approval Changes of Drugs (Interim), hereinafter referred to as the Provisions, which came int...
Process and Application of FVRCP Cat Vaccine 22 2025.01
Process and Application of FVRCP Cat Vaccine
With the increasing number of pet cats in modern families, an unprecedentedly prosperous 'cat economy' has emerged. According to data, the number of pet cats has increased to 65.36 million i...
Process Development and Optimization of Nucleic Acid Vaccines 22 2025.01
Process Development and Optimization of Nucleic Acid Vaccines
In 1989, the concept of mRNA vaccine was first mentioned. Thanks to the efforts of global nucleic acid vaccine companies represented by BioNTech and Moderna, mRNA vaccine technology has made breakthro...
Risks and Control Strategies of Scale-up in Purification Process 31 2024.12
Risks and Control Strategies of Scale-up in Purification Process
Before being launched on the market, the process development of biological products can be divided into three stages, namely, preclinical stage, phase I/II clinical stage, and phase III clinical and c...
Characterization of Rocking Bioreactors: Residence Time Distribution 30 2024.12
Characterization of Rocking Bioreactors: Residence Time Distribution
In recent years, therapeutic antibodies have played an increasingly important role in modern medicine.Due to the high dose requirements of these antibodies, there is a growing interest in technology d...
Precautions for E&L (Extractables and Leachables) Analysis and Testing 29 2024.12
Precautions for E&L (Extractables and Leachables) Analysis and Testing
Considering the differences between small molecule drugs and large molecule drugs can help determine the analytical and testing methods for E&L.Analyzing extractables and leachables (E&L) is c...
Safety Considerations in the Field of ADC 28 2024.12
Safety Considerations in the Field of ADC
Antibody-Drug Conjugate (ADC) refers to a class of biotechnological drugs in which small molecule compounds (Payload) are conjugated to targeted antibodies (Antibody) or antibody fragments through a l...
Strategies for Construction of Recombinant Escherichia coli Expression Vectors and Optimization of Cultivation Conditions 27 2024.12
Strategies for Construction of Recombinant Escherichia coli Expression Vectors and Optimization of Cultivation Conditions
PrefaceProtein expression in E. coli(Source: Reduced background expression and improved plasmid stability with pET vectors in BL21(DE3). BioTechniques 29, 1234-1238)In this post-genomic era, protein e...
Research Directions and Process Support for the Development of Novel Veterinary Vaccines 08 2024.11
Research Directions and Process Support for the Development of Novel Veterinary Vaccines
Animal vaccines belong to the category of veterinary biological products, which are an important part of biopharmaceuticals.Due to the shortcomings of traditional vaccines and the development of scien...
Mixing in Cell Culture 07 2024.11
Mixing in Cell Culture
Mixing not only ensures a uniform condition but also plays a crucial role in enhancing mass transfer, which is essential for supplying oxygen to cells and stripping carbon dioxide.The mixing in large-...
Development and Qualification of Scale-Down Models 06 2024.11
Development and Qualification of Scale-Down Models
The goal of process characterization is to demonstrate the robustness of the manufacturing process by understanding the relationship between critical operating parameters and final performance.The tec...
Cleaning and Lifespan of Protein A Affinity Chromatography Resins 05 2024.11
Cleaning and Lifespan of Protein A Affinity Chromatography Resins
Thanks to the high selectivity and volume removal rate of Protein A affinity chromatography resins for antibodies, as well as their robust impurity removal effect, Protein A affinity chromatography re...
Application of Single-use Bioreactors in Viral Vaccine Production Based on Microcarrier Culture 04 2024.11
Application of Single-use Bioreactors in Viral Vaccine Production Based on Microcarrier Culture
Vaccines have played a huge role in safeguarding national health and biological security.Since the implementation of planned immunization in China, the incidence and mortality of infectious diseases h...
A Powerful Assistant for Process Development - PuriLinx<sup>®</sup> Benchtop Chromatography System 29 2024.10
A Powerful Assistant for Process Development - PuriLinx® Benchtop Chromatography System
The PuriLinX® Benchtop Chromatography System is a chromatography system suitable for laboratory scale. It features high configuration, accurate and stable flow rate, high pressure resistance, and sen...
Process Characteristics Related to Microcarriers 15 2024.10
Process Characteristics Related to Microcarriers
With the prevalence and outbreak of various viruses, people need more research, development, and production of human and veterinary viral vaccines.High-yield vaccine production requires large-scale ce...
Removal Solutions for Endotoxins in Bioproducts Via Chromatography 08 2024.10
Removal Solutions for Endotoxins in Bioproducts Via Chromatography
Endotoxins are the primary pyrogenic contaminants in bioproducts. Even trace amounts of endotoxin entering the human body can cause fever, diarrhea, vasodilation, and even lead to fainting or death.To...
Source and Removal Methods Optimization of the Pigment Adsorption by Resins 01 2024.10
Source and Removal Methods Optimization of the Pigment Adsorption by Resins
The Impact of Adsorbed Pigments on Chromatography ResinsPigment deposition in the chromatography column not only affects its resolution and yield but also severely impacts its service life.Manifestati...
New Product | BioLink CytoLinX GB Benchtop Glass Bioreactor 20 2024.07
New Product | BioLink CytoLinX GB Benchtop Glass Bioreactor
With the development of basic research and technological iteration, the forms of drugs are becoming more diversified. From small molecules, to proteins and antibodies, to nucleic acid therapy, and the...
BioLink Commercialization Scale Chromatography Resins Change Case Sharing 10 2024.07
BioLink Commercialization Scale Chromatography Resins Change Case Sharing
ChromaX® Chromatography Resin Family from BioLinkBioLink MaXtar® ARPA Affinity Chromatography Resin and polishing resins have completed domestic replacements in many projects in China, and have succ...
Guide to Choosing CytoLinX<sup>®</sup> BR Disposable Bioreactor Bags 01 2024.07
Guide to Choosing CytoLinX® BR Disposable Bioreactor Bags
In recent years, the application of disposable bioreactors has increased gradually. Due to their relatively simple structure and operation, they reduce the workload of reactor cleaning and disinfectio...
ChromaX Chromatography Resins from BioLink for Efficient IgM Purification 24 2024.06
ChromaX Chromatography Resins from BioLink for Efficient IgM Purification
IgM antibody is a type of immunoglobulin(Ig) that mainly exists in the early stage of humoral immune response. Looking through the evolution of immunoglobulins, IgM is one of the oldest types of antib...
New Product | SynaLinX<sup>®</sup> Platinum Cured Silicon Tubing 17 2024.06
New Product | SynaLinX® Platinum Cured Silicon Tubing
Pharmaceutical grade silicone tubing and braided silicone tubing are the best choices for fluid transfer tubing in medical and biopharmaceutical applications. Strict control over the raw materials and...
Processing Development and Optimization: Practices and Solutions for Downstream Protein Purification Technology 10 2024.06
Processing Development and Optimization: Practices and Solutions for Downstream Protein Purification Technology
Protein purification is a essential part of downstream biological technology. Mastering the basic theory and operation of protein purification technology plays an important role in the further study o...
New Product | FiltraLinX<sup>®</sup> Benchtop Manual Hollow Fiber TFF System 03 2024.06
New Product | FiltraLinX® Benchtop Manual Hollow Fiber TFF System
FiltraLinX® Benchtop Manual Hollow Fiber TFF System is an economical, practical, stable, and durable tangential flow filtration system that can meet the filtration area requirements from 0.017 to 5.1...
CytoLinX<sup>®</sup> Electrode Sleeve Components 30 2024.05
CytoLinX® Electrode Sleeve Components
Throughout the biopharmaceutical process, the use of bioreactors accounts for a high proportion, with a significant impact on the final product. CytoLinX® Electrode Sleeve Assembly ProcessIn the cell...
New Product | SynaLinX<sup>®</sup> B-Flex™ Thermoplastic Tubing 18 2024.05
New Product | SynaLinX® B-Flex™ Thermoplastic Tubing
Bio-Link selects medical-grade imported raw materials and employs unique production processes to create the high-performance and cost-effective SynaLinX® B-Flex™ thermoplastic tubing, supporting bio...
Bio-Link's Second Generation Tube Sealer, Unleashing a Light Fast Excellent Efficient Experience 06 2024.05
Bio-Link's Second Generation Tube Sealer, Unleashing a Light Fast Excellent Efficient Experience
With the increasing demand for disposable solutions in pharmaceutical manufacturing processes, rapid and efficient sterile disconnection has become a key component of the overall solutions.Based on cu...
New Product | BioLink CytoLinX<sup>®</sup> GB Benchtop Bioreactor 08 2023.12
New Product | BioLink CytoLinX® GB Benchtop Bioreactor
With the development of basic research and technological iteration, drug forms are becoming more and more diverse. From small molecules, proteins and antibodies, nucleic acid therapy, to cell therapy ...
Compatibility Considerations for Single-use Technology in ADC Coupling Process 07 2023.12
Compatibility Considerations for Single-use Technology in ADC Coupling Process
Antibody-drug conjugates (ADCs) are a rapidly developing class of biotherapeutic cancer drugs in the past three years. ADCs use linkers to connect monoclonal antibodies (mAbs) with payloads...
Extractables & Leachables: What's the Difference? How to Deal with It? 06 2023.12
Extractables & Leachables: What's the Difference? How to Deal with It?
With the integration of single-use systems (SUS) into downstream processing, which brings them closer to the final drug product, consideration of extractables and leachables (E&L) has become a key...
Purification Techniques | Is the Effect of Hydrophobic Chromatography Related to Temperature? 05 2023.12
Purification Techniques | Is the Effect of Hydrophobic Chromatography Related to Temperature?
In the beginning of winter, although the weather is getting colder, the experimental staff's enthusiasm for their work is undiminished. Recently, we often hear various complaints from the experime...
Purification Techniques | How to ''Buy Right and Not Expensive for Affinity Chromatography'' 04 2023.12
Purification Techniques | How to ''Buy Right and Not Expensive for Affinity Chromatography''
As a representative of high resolution and good compatibility in downstream separation and purification technology, chromatography technology is widely used in the large-scale preparation of biologica...
Optimization Strategy for Downstream Process of Lentivirus 03 2023.12
Optimization Strategy for Downstream Process of Lentivirus
Lentivirus vector (LV) is an enveloped virus of the Retroviridae family, which can stably integrate and express transgenes in dividing and non-dividing cells. It has the advantages of large packaging ...
Application Cases and Key Points of Purifying His-tagged Proteins with Ni-based Resins 02 2023.12
Application Cases and Key Points of Purifying His-tagged Proteins with Ni-based Resins
The His tag has become the most commonly used affinity tag due to its small molecular weight, strong load ability to metal ions, and the ability to maintain binding to the resin under denaturing condi...
Exosome Downstream Process Solutions 01 2023.12
Exosome Downstream Process Solutions
In 2013, the Nobel Prize in Physiology or Medicine was awarded to American scientists James Rothman and Randy Schekman and German scientist Thomas Zudhof for their work in the field of regulating mech...
Application Tips and Optimization Strategies for Hydroxyapatite 30 2023.11
Application Tips and Optimization Strategies for Hydroxyapatite
Hydroxyapatite is an inorganic pure-phase chromatography medium that is calcined at high temperature into spheres with stable spherical structure and relatively uniform particle size. There are multip...
Perfusion Application Case of CytoLinX<sup>®</sup> WB Single-Use Cell Culture Bag 29 2023.11
Perfusion Application Case of CytoLinX® WB Single-Use Cell Culture Bag
As one of the important processes for current mammalian cell culture, perfusion culture can not only provide a stable environment conducive to cell growth by continuously removing by-products and addi...
BioHub<sup>®</sup> Series of Single-Use Cell Culture Consumables 28 2023.11
BioHub® Series of Single-Use Cell Culture Consumables
Usually in biopharmaceutical research and development, early process exploration is the top priority, and cell culture is the beginning of everything. To protect the cell culture of biopharmaceutical ...
Purification Techniques | Ion Exchange Chromatography to Remove Endotoxins 27 2023.11
Purification Techniques | Ion Exchange Chromatography to Remove Endotoxins
During R&D and production, when endotoxin is mentioned, is the first thought that comes to mind 'a difficult opponent'? So, how to give the 'opponent' a powerful and effective ...
BioHub<sup>®</sup> Series of Single-Use Process Bags: The Experts in Dispensing Solutions 23 2023.10
BioHub® Series of Single-Use Process Bags: The Experts in Dispensing Solutions
Located in Nantong City, Jiangsu Province, with a total area of about 27,000 square metres, the production base of BioLink's single-use consumables has a planned total annual capacity of 2 millio...
Optimization of Antibody Scale-Up Production Based on Single-Use Technology 16 2023.10
Optimization of Antibody Scale-Up Production Based on Single-Use Technology
In order to further reduce costs and increase efficiency, an increasing number of pharmaceutical companies are adopting the process of pre-cultivating N-1 generation seed in N vessels. This article in...
Purification Techniques | How to Creatively Remove Aggregates? 09 2023.10
Purification Techniques | How to Creatively Remove Aggregates?
Dr. William Hallett from the FDA delivered a keynote presentation at the 2016 CHI Annual Conference, discussing the impact of protein aggregates on immunogenicity. The presentation highlighted that pr...
Purification Techniques | Column Selection for Chromatography 24 2023.09
Purification Techniques | Column Selection for Chromatography
The determination of purification process often requires a series of steps, including resin screening, exploration of potential resin application processes, small-scale trial confirmation, and scale-u...
The Subtle Relationship Between Cells and Bubbles, How Does BioLink 23 2023.09
The Subtle Relationship Between Cells and Bubbles, How Does BioLink
With the booming development of biopharmaceutical industry, antibody drugs, gene therapy and cell therapy are getting more and more attention. Bioreactor is one of the core equipment in biotechnology,...
How to Prevent Nucleases contamination? 15 2023.09
How to Prevent Nucleases contamination?
Deoxyribonuclease (DNase) and ribonuclease (RNase) are hydrolases that can cleave the phosphodiester bond of polynucleotide chains to degrade DNA and RNA molecules. Nuclease widely exists in the envir...
New Product | CytoLinX<sup>®</sup> BR Single-Use Bioreactor 01 2023.09
New Product | CytoLinX® BR Single-Use Bioreactor
Single-use bioreactors have always been a 'choke point' for local biomanufacturing companies due to the difficult manufacturing process and its self-control logic. BioLink has always been...
Product Introduction | CytoLinX<sup>®</sup> BR Single-Use Bioreactor 17 2023.08
Product Introduction | CytoLinX® BR Single-Use Bioreactor
Single-use bioreactors have always been a 'choke point' for biomanufacturing companies due to the difficult manufacturing process and its self-control logic. BioLink has always been committed...
How to Achieve Efficient Production “Acceleration” for the Scarce Herpes Zoster Vaccine? 16 2023.08
How to Achieve Efficient Production “Acceleration” for the Scarce Herpes Zoster Vaccine?
Herpes zoster (commonly known as shingles, belt of fire, or snake wrapping around the waist) is an infectious skin disease caused by the reactivation of the varicella-zoster virus that lies dormant in...
Purification Techniques | A Tenfold Increase in Purification Efficiency for High Molecular Weight Macromolecules: A Remarkable Breakthrough 15 2023.08
Purification Techniques | A Tenfold Increase in Purification Efficiency for High Molecular Weight Macromolecules: A Remarkable Breakthrough
Macromolecules, including viruses, VLPs (virus-like particles), viral vectors, and IgM antibodies, typically possess molecular weights surpassing several hundred kilodaltons (kDa). In both scientific ...
Cell Culture Products Functions 08 2023.05
Cell Culture Products Functions
The function of cell culture products in upstream bioprocessing is to support the growth and expansion of cells.
The Development Trend of Disposable Bioprocessed Products 13 2023.02
The Development Trend of Disposable Bioprocessed Products
Cost savings: Disposable bioprocessed products can be more cost-effective in the long run, as they eliminate the need for expensive cleaning and sterilization procedures.
Downstream Protein Chromatography Applications 13 2023.02
Downstream Protein Chromatography Applications
Downstream bioprocessing refers to the later stages of the bioprocessing production process, which typically involve purifying and refining the bioprocessing product.
Downstream Bioprocesses-the Role of Filtration 13 2023.02
Downstream Bioprocesses-the Role of Filtration
In downstream bioprocessing, processing filtration is used to remove impurities and contaminants from the bioprocessing product.
Single-Use Bioprocessing Benefits Humans 13 2023.02
Single-Use Bioprocessing Benefits Humans
Single-use bioprocessing products have numerous benefits, particularly in the fields of medicine and biotechnology.
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