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New Product | Bio-Link CytoLinX GB Benchtop Bioreactor 08 2023.12
New Product | Bio-Link CytoLinX GB Benchtop Bioreactor
With the development of basic research and technological iteration, drug forms are becoming more and more diverse. From small molecules, proteins and antibodies, nucleic acid therapy, to cell therapy ...
Compatibility Considerations for Single-use Technology in ADC Coupling Process 07 2023.12
Compatibility Considerations for Single-use Technology in ADC Coupling Process
Antibody-drug conjugates (ADCs) are a rapidly developing class of biotherapeutic cancer drugs in the past three years. ADCs use linkers to connect monoclonal antibodies (mAbs) with payloads (Figure 1)...
Extractables & Leachables: What's the Difference? How to Deal with It? 06 2023.12
Extractables & Leachables: What's the Difference? How to Deal with It?
With the integration of single-use systems (SUS) into downstream processing, which brings them closer to the final drug product, consideration of extractables and leachables (E&L) has become a key...
Purification Techniques | Is the Effect of Hydrophobic Chromatography Related to Temperature? 05 2023.12
Purification Techniques | Is the Effect of Hydrophobic Chromatography Related to Temperature?
In the beginning of winter, although the weather is getting colder, the experimental staff's enthusiasm for their work is undiminished. Recently, we often hear various complaints from the experime...
Purification Techniques | How to 04 2023.12
Purification Techniques | How to
As a representative of high resolution and good compatibility in downstream separation and purification technology, chromatography technology is widely used in the large-scale preparation of biologica...
Optimization Strategy for Downstream Process of Lentivirus 03 2023.12
Optimization Strategy for Downstream Process of Lentivirus
Lentivirus vector (LV) is an enveloped virus of the Retroviridae family, which can stably integrate and express transgenes in dividing and non-dividing cells. It has the advantages of large packaging ...
Application Cases and Key Points of Purifying His-tagged Proteins with Ni-based Resins 02 2023.12
Application Cases and Key Points of Purifying His-tagged Proteins with Ni-based Resins
The His tag has become the most commonly used affinity tag due to its small molecular weight, strong load ability to metal ions, and the ability to maintain binding to the resin under denaturing condi...
Exosome Downstream Process Solutions 01 2023.12
Exosome Downstream Process Solutions
In 2013, the Nobel Prize in Physiology or Medicine was awarded to American scientists James Rothman and Randy Schekman and German scientist Thomas Zudhof for their work in the field of regulating mech...
Application Tips and Optimization Strategies for Hydroxyapatite 30 2023.11
Application Tips and Optimization Strategies for Hydroxyapatite
Hydroxyapatite is an inorganic pure-phase chromatography medium that is calcined at high temperature into spheres with stable spherical structure and relatively uniform particle size. There are multip...
Perfusion Application Case of CytoLinX® WB Single-Use Cell Culture Bag 29 2023.11
Perfusion Application Case of CytoLinX® WB Single-Use Cell Culture Bag
As one of the important processes for current mammalian cell culture, perfusion culture can not only provide a stable environment conducive to cell growth by continuously removing by-products and addi...
BioHub® Series of Single-Use Cell Culture Consumables 28 2023.11
BioHub® Series of Single-Use Cell Culture Consumables
Usually in biopharmaceutical research and development, early process exploration is the top priority, and cell culture is the beginning of everything. To protect the cell culture of biopharmaceutical ...
Purification Techniques | Ion Exchange Chromatography to Remove Endotoxins 27 2023.11
Purification Techniques | Ion Exchange Chromatography to Remove Endotoxins
During R&D and production, when endotoxin is mentioned, is the first thought that comes to mind "a difficult opponent"? So, how to give the "opponent" a powerful and effective ...
BioHub Series of Single-Use Process Bags: The Experts in Dispensing Solutions 23 2023.10
BioHub Series of Single-Use Process Bags: The Experts in Dispensing Solutions
Located in Nantong City, Jiangsu Province, with a total area of about 27,000 square metres, the production base of Bio-Link's single-use consumables has a planned total annual capacity of 2 millio...
Optimization of Antibody Scale-Up Production Based on Single-Use Technology 16 2023.10
Optimization of Antibody Scale-Up Production Based on Single-Use Technology
In order to further reduce costs and increase efficiency, an increasing number of pharmaceutical companies are adopting the process of pre-cultivating N-1 generation seed in N vessels. This article in...
Purification Techniques | How to Creatively Remove Aggregates? 09 2023.10
Purification Techniques | How to Creatively Remove Aggregates?
Dr. William Hallett from the FDA delivered a keynote presentation at the 2016 CHI Annual Conference, discussing the impact of protein aggregates on immunogenicity. The presentation highlighted that pr...
Purification Techniques | Column Selection for Chromatography 24 2023.09
Purification Techniques | Column Selection for Chromatography
The determination of purification process often requires a series of steps, including resin screening, exploration of potential resin application processes, small-scale trial confirmation, and scale-u...
The Subtle Relationship Between Cells and Bubbles, How Does Bio-Link 23 2023.09
The Subtle Relationship Between Cells and Bubbles, How Does Bio-Link
With the booming development of biopharmaceutical industry, antibody drugs, gene therapy and cell therapy are getting more and more attention. Bioreactor is one of the core equipment in biotechnology,...
How to Prevent Nucleases contamination? 15 2023.09
How to Prevent Nucleases contamination?
Deoxyribonuclease (DNase) and ribonuclease (RNase) are hydrolases that can cleave the phosphodiester bond of polynucleotide chains to degrade DNA and RNA molecules. Nuclease widely exists in the envir...
New Product | CytoLinX BR Single-Use Bioreactor 01 2023.09
New Product | CytoLinX BR Single-Use Bioreactor
Single-use bioreactors have always been a "choke point" for local biomanufacturing companies due to the difficult manufacturing process and its self-control logic. Bio-Link has always been c...
Product Introduction | CytoLinX BR Single-Use Bioreactor 17 2023.08
Product Introduction | CytoLinX BR Single-Use Bioreactor
Single-use bioreactors have always been a "choke point" for biomanufacturing companies due to the difficult manufacturing process and its self-control logic. Bio-Link has always been committ...
How to Achieve Efficient Production “Acceleration” for the Scarce Herpes Zoster Vaccine? 16 2023.08
How to Achieve Efficient Production “Acceleration” for the Scarce Herpes Zoster Vaccine?
Herpes zoster (commonly known as shingles, belt of fire, or snake wrapping around the waist) is an infectious skin disease caused by the reactivation of the varicella-zoster virus that lies dormant in...
Purification Techniques | A Tenfold Increase in Purification Efficiency for High Molecular Weight Macromolecules: A Remarkable Breakthrough 15 2023.08
Purification Techniques | A Tenfold Increase in Purification Efficiency for High Molecular Weight Macromolecules: A Remarkable Breakthrough
Macromolecules, including viruses, VLPs (virus-like particles), viral vectors, and IgM antibodies, typically possess molecular weights surpassing several hundred kilodaltons (kDa). In both scientific ...
Cell Culture Products Functions 08 2023.05
Cell Culture Products Functions
The function of cell culture products in upstream bioprocessing is to support the growth and expansion of cells.
The Development Trend of Disposable Bioprocessed Products 13 2023.02
The Development Trend of Disposable Bioprocessed Products
Cost savings: Disposable bioprocessed products can be more cost-effective in the long run, as they eliminate the need for expensive cleaning and sterilization procedures.
Downstream Protein Chromatography Applications 13 2023.02
Downstream Protein Chromatography Applications
Downstream bioprocessing refers to the later stages of the bioprocessing production process, which typically involve purifying and refining the bioprocessing product.
Downstream Bioprocesses-the Role of Filtration 13 2023.02
Downstream Bioprocesses-the Role of Filtration
In downstream bioprocessing, processing filtration is used to remove impurities and contaminants from the bioprocessing product.
Single-use Bioprocessing Benefits Humans 13 2023.02
Single-use Bioprocessing Benefits Humans
Single-use bioprocessing products have numerous benefits, particularly in the fields of medicine and biotechnology.