New Product | CytoLinX BR Single-Use Bioreactor


Single-use bioreactors have always been a "choke point" for local biomanufacturing companies due to the difficult manufacturing process and its self-control logic. Bio-Link has always been committed to providing advanced and efficient process solutions for the life science field.

After the team's relentless research, Bio-Link recently launched CytoLinX BR single-use perfusion bioreactor and matching consumables, covering the specifications of 50, 200, 500, 1000, 2000 L.


Figure 1. Family diagram of CytoLinX BR 50-2000 L standard bioreactors

CytoLinX BR is a single-use bioreactor based on distributed control systems (DCS) . The underlying logic is built by Siemens PCS 7, which covers the automation needs from R&D to production and from a single unit to the entire upstream plant, and its automation logic complies with the ISA 88 control standards.

The software is designed to comply with GMP and 21 CFR Part 11 requirements. For ease of use , the Intuitive and concise interface design of CytoLinX BR software interface has been designed to be extremely simple make all functions clear at a glance and largely meet customer needs


Figure 2. CytoLinX BR control interface

The automatic control system has real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control and other functions, and has a stable performance of pH, DO, temperature control.


Figure 3. Results of CytoLinX BR high cell density culture test

For more efficient mixing effect, Bio-Link has launched a new bottom dial design that maintains a high linear KLa. It also provides microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions to meet the tough needs of a variety of cell culture.

CytoLinX ™ BR single-use tank bioreactor features include:

► User-friendly control interface

► Plug and play

► One control cabinet for multiple tanks

► Stable DCS control system in accordance with ISA 88 control standards

► Flexible configuration, partially customisable according to user requirements

► Provide comprehensive FAT, SAT, IQ, OQ documentation and services

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Want to know more about Bio-Link bioprocessing products? Feel free to contact Bio-Link now!