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BioHub® BM Single-use Magnetic Mixing System

Through the magnetic coupling mechanism, the motor drives the single-use stirring blades in the stirring bag to rotate, which can meet various needs such as liquid-liquid mixing, solid-liquid mixing, etc.

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BioHub® BM Single-use Magnetic Mixing System has a nice and neat appearance and is easy to clean, handle and use. The system is specially designed for production mixing in biotechnology and pharmaceuticals to facilitate lab research, process development, and GMP production.


The system provides an ideal solution for efficient solid/liquid mixing applications. As a flexible mobile mixing platform, the system provides effective and sustainable single-use mixing solutions for different volumes and application types. The system has demonstrated excellent performance in buffer and medium preparation.



Video of BM Single-use Magnetic Mixing System

Features of BioHub® BM Single-use Magnetic Mixing System

•    Wide volume range

The BioHub® BM Single-use Magnetic Mixing System covers various volumes, including 50 L, 100 L, 200 L, 400 L, 500 L, 650 L, 1000 L, 1500 L, 2000 L, 2500 L, and 3000 L, so as to meet the requirements of scale-up from R&D to mass production; other volumes can be customized.


•    Wide working volume range

The working volume is usually 20%–110% of the mixing system volume.


•    Low residual liquid

With an inclined bottom at an angle of 2–5° , the liquid outlet is located at the lowest level of the whole equipment, ensuring a low residual liquid ( ≤ 20 mL) and reducing the loss of feed liquid (dwell volume ≤ 2.5 L for 2500 L and ≤ 3 L for 3000 L).


•    Precise mixing

The motor is from Oriental Motor. The rotation speed precision is ±2 rpm. The motor is at a fixed time and fixed speed, can be instantly started and stopped, and no pre-heating or magnetizing is required.


•    Polished and wire-drawn

The whole device is made of SS304L with anti-fingerprint polishing (Ra ≤ 0.8 μm), preventing injuries to soft bags.


•    Compact structure

The equipment has a compact plug-and-run structure design and there is no need to install a driver or controller. The structural design is friendly to users. The shelf and handle can well protect the weight sensor.


•    No condensation

Dimple jackets at four sides enables the temperature of the feed liquid to be controlled in a short time. Also, insulation layers are provided outside the jackets, which helps to avoid condensation when the temperature of the feed liquid is lower or higher than the ambient temperature, meeting the requirements of clean workshops.


•    Easy cleaning

No obvious arrangement of wires can be observed on the surface of the equipment. All wiring is arranged inside the equipment (with waterproof connectors) for a neat appearance, making it easy to transfer the equipment inside a workshop and clean it after use.


•   Modular design

Various modules are available for different customer demands, including mixing, weighing, temperature control, pH, cond, peristaltic pump, etc. All core components and parts are from high-end brands, ensuring the stable control of critical parameters.


•   Stable hardware design

The design of window/manual control on the side of the mixing bin facilitates the installation of bags and allows the visual inspection of the mixing status.

The control interface and mixing bin height are reasonably designed for easier operation.

The rotatable electric-control mixing bin makes it easier to use and clean from multiple angles.

The liquid outlet line and safety valve are added to meet the needs of safety and convenience.


•    Reliable software control

The standard configuration of the genuine Windows 10 Enterprise Edition, Advantech IPC, and Siemens PLC ensures smooth operations.

Permission management, audit trail, batch data export, data integrity,  and related functions are available, meeting the data integrity requirements of 21CFR Part 11 and satisfying the requirements for GMP production.

Due to the flexible process formula function newly added, customers can manually add various standard formulas. Also, the standard formula recording function coming with the program can save the customer's repeated efforts, reducing the risk of use.


•    Independent control of production

BioLink's manufacturing site covers an area of 10,000 m2 and is equipped with independent sheet metal cutting equipment, bending equipment, polishing equipment,etc. From raw materials and steel materials to product delivery, the entire production process is independently controlled by BioLink to assure product quality and control the delivery time.



Applications of BioHub® BM Single-use Magnetic Mixing System

•   Medium preparation

•   Buffer preparation

•   Downstream intermediate product processing

•   Bulk purification

•   Semi-finished product preparation


Advantages of BioHub® BM Single-use Magnetic Mixing System

The BioHub® BM Single-use Magnetic Mixing System works through a magnetic coupling motor to drive the single-use stirring paddles in the mixing bag to rotate, and is equipped with physical shaft seals. This system is safe, reliable, stable and efficient. Working together with a stainless steel bin, it can meet various liquid-liquid mixing and solid-liquid mixing needs, suitable for medium preparation, buffer preparation, intermediate mixing, semi-finished product preparation, and final pharmaceutical products mixing.


The mixing system consists of a stainless steel bin, a control system, a magnetic mixing motor, and a single-use mixer bag. The modular design allows for flexible combinations of different functions on demand, such as mixing, weighing, feedback-controlled temperature monitoring, pH, and conductivity, while supporting high levels of customization to the complex needs of customers. The system also provides three-level permissions and electronic signature to meet the data integrity needs of pharmaceutical customers.


Specifications of BioHub® BM Single-use Magnetic Mixing System

Technical Parameters of BMC Integrated Mixer


MX50MX100MX200MX400MX500MX1000MX1500MX2000MX2500MX3000

Dimension

(mm)

1087*679

*1165

1187*779

*1165

1318*914

*1213

1451*1045 *13131501*1099 *14131718*1315 *1648

2022*1408

*1724

2697*1452

*1568

2697*1452

*1738

2697*1452

*1918

Weight (kg)

Unjacket-

ed:190

Jacketed:

225

Unjacket-

ed:215

Jacketed:

260

Unjacket-

ed:250

Jacketed:

320

Unjacket-

ed:310

Jacketed:

400

Unjacket-

ed:335

Jacketed:

435

Unjacket-

ed:455

Jacketed:

646

Unjacket-

ed:626

Jacketed:

895

Unjacket-

ed:985

Jacketed:

1295

Unjacket-

ed:1075

Jacketed:

1420

Unjacket-

ed:1165

Jacketed:

1545

MaterialSS304L
RoughnessRa ≤ 0.8 μm
JacketOptional
Heat exchange
area (m²)
0.50.641.021.381.8 3.14.056.2  77.8
Volume in the
jacket (L)
2.83.24.38.712.420.626.444.252.664.8
Maximum
working
pressure in the
jacket (bar)
6666666666
Mixing unitThe system is equipped with Oriental Motor and magnetic coupling mixing, with a speed accuracy of ± 5 rpm
Weighing unitMETTLER hygienic weighing module, with a weighing accuracy of 0.3%
Online
temperature
module
WIKA
Online conduc-
tivity module
Hamilton
Online pH
module
Hamilton
Data integrityThree-level permission, audit trail, batch record export, interface with a central console, etc.


Technical Parameters of BMP Integrated Mixer


MX50MX100MX200MX400MX500MX650MX1000MX2000
Dimension(mm)1071*630*11651168*735*11651273*830*11651434*977*13251581*1130*12631581*1130*14231725*1270*16001770*1285*2830
Weight (kg)Unjacketed:199
jacketed:227
Unjacketed:215
jacketed:255
Unjacketed:245
jacketed: 300
Unjacketed:297
jacketed:375
Unjacketed:219
jacketed:405
Unjacketed:365
jacketed:465
Unjacketed:468
jacketed:652
Unjacketed:1085
jacketed:1410
MaterialSS304L
RoughnessRa ≤ 0.8 μm
JacketOptional
Heat exchange
area (m²)
0.50.641.021.391.82.23.15.6
Volume in the
jacket (L)
2.83.24.38.712.416.620.644.2
Maximum
working
pressure in the
jacket (bar)
66666666
Mixing unitThe system is equipped with Oriental Motor and magnetic coupling mixing, with a speed accuracy of ± 5 rpm
Weighing unitMETTLER hygienic weighing module, with a weighing accuracy of 0.3%
Online
temperature
module
Hamilton
Online conduc-
tivity module
Hamilton
Online pH
module
Hamilton
Data integrityThree-level permission, audit trail, batch record export, interface with a central console, etc.


Ordering Information:

BM Integrated Mixer:

Name Rules for BM Single-use Integrated Magnetic Mixing System

Product Name: Volume + Integrated mixing system

Cat. No.: A + B


Drawing No.: A-GAD
A
B
Initial letterSeries No.VolumeJacketScreenpH moduleCond moduleTemperature
module
Pinter
Z (Mettler sensor
+ Self-developed
transmitter)
BMP0050YI: Advantech IPCH: HamiltonH: HamiltonT: Surface
mount
P: Yes
A (Mettler
sensor + Mettler
transmitter)
BMC0100NS: Siemens HMIM: Mettler +
M80
M: Mettler +
M80
C: Plug-inN: No
K (Mettler
module + Self-
developed
transmitter)
BMM
(Magnetic
coupling)
0200
T: Siemens 12’’IPCK: NoBrand is
Brightek
R (Mettler
sensor + Mettler
transmitter)
BMF
(Magnetic
levitation)
0300K: Siemens 15’’IPC
N (No weighing)
0400M: Kunlun TongtaiP: NoC: NoC for standard
(default WIKA)
Z for standard0500I for standardH for standardH for standard

0650    Note:
    BMM indicates compatibility with Merck Generation II, using magnetic
    coupling.
    BMF indicates compatibility with Merck Generation I magnetic levitation.
    There are two motor options: imported Lev and domestic Cheer. Catalog
    numbers are not differentiated; please specify clearly when ordering,
    with Cheer being the preferred choice.
1000
1500
2000
2500
3000


BM Split Series

Mixing tank


NameFormCat.No.Configuration                           Description
Single-use mixing tank
MX50
Cubic stainless steel tankBMPMX50L001UnjacketedBMP split series
Cubic stainless steel tankBMPMX50L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX50L003Jacketed
Cubic stainless steel tankBMPMX50L004Jacketed, with weighing
Single-use mixing tank
MX100
Cubic stainless steel tankBMPMX100L001Unjacketed
Cubic stainless steel tankBMPMX100L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX100L003Jacketed
Cubic stainless steel tankBMPMX100L004Jacketed, with weighing
Single-use mixing tank
MX200
Cubic stainless steel tankBMPMX200L001Unjacketed
Cubic stainless steel tankBMPMX200L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX200L003Jacketed
Cubic stainless steel tankBMPMX200L004Jacketed, with weighing
Single-use mixing tank
MX400
Cubic stainless steel tankBMPMX400L001Unjacketed
Cubic stainless steel tankBMPMX400L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX400L003Jacketed
Cubic stainless steel tankBMPMX400L004Jacketed, with weighing
Single-use mixing tank
MX500
Cubic stainless steel tankBMPMX500L001Unjacketed
Cubic stainless steel tankBMPMX500L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX500L003Jacketed
Cubic stainless steel tankBMPMX500L004Jacketed, with weighing
Single-use mixing tank
MX650
Cubic stainless steel tankBMPMX650L001Unjacketed
Cubic stainless steel tankBMPMX650L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX650L003Jacketed
Cubic stainless steel tankBMPMX650L004Jacketed, with weighing
Single-use mixing tank
MX1000
Cubic stainless steel tankBMPMX1000L001Unjacketed
Cubic stainless steel tankBMPMX1000L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX1000L003Jacketed
Cubic stainless steel tankBMPMX1000L004Jacketed, with weighing
Single-use mixing tank
MX1500
Cubic stainless steel tankBMPMX1500L001Unjacketed
Cubic stainless steel tankBMPMX1500L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX1500L003Jacketed
Cubic stainless steel tankBMPMX1500L004Jacketed, with weighing
Single-use mixing tank
MX2000
Cubic stainless steel tankBMPMX2000L001Unjacketed
Cubic stainless steel tankBMPMX2000L002Unjacketed, with weighing
Cubic stainless steel tankBMPMX2000L003Jacketed
Cubic stainless steel tankBMPMX2000L004Jacketed, with weighing


NameFormCat.No.ConfigurationDescription
Single-usemixingtank
MX50
CubicstainlesssteeltankBMCMX50L001UnjacketedBMCsplitseries
CubicstainlesssteeltankBMCMX50L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX50L003Jacketed
CubicstainlesssteeltankBMCMX50L004Jacketed, with weighing
Single-usemixingtank
MX100
CubicstainlesssteeltankBMCMX100L001Unjacketed
CubicstainlesssteeltankBMCMX100L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX100L003Jacketed
CubicstainlesssteeltankBMCMX100L004Jacketed, with weighing
Single-usemixingtank
MX200
CubicstainlesssteeltankBMCMX200L001Unjacketed
CubicstainlesssteeltankBMCMX200L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX200L003Jacketed
CubicstainlesssteeltankBMCMX200L004Jacketed, with weighing
Single-usemixingtank
MX500
CubicstainlesssteeltankBMCMX500L001Unjacketed
CubicstainlesssteeltankBMCMX500L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX500L003Jacketed
CubicstainlesssteeltankBMCMX500L004Jacketed, with weighing
Single-usemixingtank
MX1000
CubicstainlesssteeltankBMCMX1000L001Unjacketed
CubicstainlesssteeltankBMCMX1000L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX1000L003Jacketed
CubicstainlesssteeltankBMCMX1000L004Jacketed, with weighing
Single-usemixingtank
MX1500
CubicstainlesssteeltankBMCMX1500L001Unjacketed
CubicstainlesssteeltankBMCMX1500L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX1500L003Jacketed
CubicstainlesssteeltankBMCMX1500L004Jacketed, with weighing
Single-usemixingtank
MX2000
CubicstainlesssteeltankBMCMX2000L001Unjacketed
CubicstainlesssteeltankBMCMX2000L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX2000L003Jacketed
CubicstainlesssteeltankBMCMX2000L004Jacketed, with weighing
Single-usemixingtank
MX2500
CubicstainlesssteeltankBMCMX2500L001Unjacketed
CubicstainlesssteeltankBMCMX2500L002Unjacketed, with weighing
CubicstainlesssteeltankBMCMX2500L003Jacketed
CubicstainlesssteeltankBMCMX2500L004Jacketed, with weighing



*Please contact your local sales and technical support at the earliest time possible to discuss and confirm the control requirements, and verify the correct model and Part number (PN) of the control cabinet.
Technical Hotline: 400-058-9000


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