Chrom-LinX^® Automated Chromatography Column

Name: Chrom-LinX ® Automated Chromatography Column
Brand: Bio-Link
Price: 100 USD

Chrom-LinX^® Automated Chromatography Column are designed for downstream purification of biopharmaceuticals. They are operated by automated control software (with the BioLink Packing-LinX^® column packing workstation), to minimize the cumbersome manual operation of conventional columns. Column packing with the BioLink Slurry-LinX^® series slurry tank allows the entire process to remain in a closed environment for most of the time, minimizing the risk of exposure and contamination of the chromatography resin and homogenizing solution.

Chrom-LinX^® Automated Chromatography Column have been carefully designed and proven to provide excellent performance with most of the different types of resin. They are compatible with the ChromaX^® chromatography resins from BioLink, and perform very well when filled with Chromstar FF and MaXtar series resins of high rigidity and flow rate. The software in the workstation presets the packing method of relevant resins, which can simplify the packing process and improve the production efficiency.

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Overview Features Specifications Material Workstation Ordering Information Contact us

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.

Overview of Chrom-LinX^® Automated Chromatography Column

Chrom-LinX^® Automated Chromatography Column works in a low-pressure and axial compression mode as a standardized equipment with ID of 450, 600, 800, 1000, 1200 mm and column tube height of 700 mm (1000 mm customizable), making itself suitable for the manufacturing of various types and scales of bioproducts.

The exhaust structure of the columns has been carefully designed and tested to allow for easy exhaust and cleanliness of the column head, reducing cleaning and maintenance steps. The design of the column head distribution plate ensures uniform distribution of liquid flow. The packing process is controlled by software in the column packing workstation, which enables intelligent loading and unloading, as well as automated packing, dismantling and maintenance operations through programming, ensuring the stability and reproducibility of packing. A pre-homogenized resin is pumped into the column through the inlet at the column bottom. The column head is driven upwards by a servo motor, and after pumping in a sufficient amount of homogenate, the column head moves downwards to pack the resin. The speed of the column head can be set by software, and the accuracy of the movement distance can reach 1mm. The height of the column bed can be precisely controlled so that the resin forms a uniform and stable bed structure within the column.

Features of Chrom-LinX^® Automated Chromatography Column

Column tube is acrylic structure, clear vision, column bed position visible.
Sanitary design, in line with GMP requirements.
Material safety, in line with the regulatory requirements.
Scientific design, no clean dead corner.
Can be used for a variety of packing.
Specifications of inner diameter: 300, 450, 600, 800, 1000, 1200 mm.
Height range: 550 and 570 mm.
Screen aperture: 10μm and 20μm are optional.

Specifications of Chrom-LinX^® Automated Chromatography Column

Specification	Chrom-LinX 450/700	Chrom-LinX 600/700	Chrom-LinX 800/700	Chrom-LinX 1000/700
Column inner diameter (mm)	450	600	800	1000
Column bed height (cm)	5-30	5-30	5-30	5-30
Column head lift height (cm)	0-68	0-68	0-68	0-62
Minimum operating height (mm)	1690	1750	1790	2000
Maximum operating height (mm)	2365	2410	2470	2690
Maximum maintenance height (mm)	2480	2540	2610	2850
Maximum operating pressure	0.3 MPa (3 bar or 43.5 psi)
Empty column weight (kg)	500	1000	1700	2630
Footprint (mm×mm)	1160×610	1350×800	1510×1000	1740×1220
Operating temperature	2-40℃
Pore size of sieve plate	10μm, 20μm

Material of Chrom-LinX^® Automated Chromatography Column

Chrom-LinX^® Auto Automated Chromatography Columns are made of materials suitable for biopharmaceutical production. The structural materials conform to ASME biological processing equipment standards, and the wetted polymer materials and elastic materials meet the requirements of USP<88> in vivo biological reactivity test and FDA 21 CFR Part 177. All materials contain no ingredients of animal origin and comply with the regulations in EMA/410/01 2nd edition. The parts used are traceable back to the product batch. Wetted parts can withstand most chemical reagents commonly used in chromatography, such as buffers or organic reagents for adsorption, elution, washing and preservation, as well as disinfectant solutions.

Parts	Material description
Column tube	Acrylic
O-ring	EPDM+UPE
Distribution plate	PP
Column head adapter	316L stainless steel
Column head	2205 stainless steel
Net ring	316L/904L stainless steel
Tubing/Fittings	316L stainless steel
Medium valve body	PP
Support	304 stainless steel
Caster	Nylon + polyurethane

Packing-LinX^® Column Packing Workstation

The Packing-LinX^® Column Loading Workstation enables 21 CFR Part 11 compliant packing operations. Chromatography columns are operated via the touch screen of the workstation. The workstation supports functions including venting, filling, disassembly, and maintenance besides corresponding programs, which can be selected and set by the operator as needed. During the packing process, the equipment will stop automatically when the set compression factor or height is reached, or the operator can stop it manually at any time.

Packing-LinX Column Packing Workstation

Ordering Information of Chrom-LinX^® Automated Chromatography Column

Chromatography column	Pore size of sieve plate	Product code
Chrom-LinX Auto 450/700		2345-1221
Chrom-LinX Auto 600/700		2360-1221
Chrom-LinX Auto 800/700	20μm	2380-1221
Chrom-LinX Auto 1000/700		2310-1221
Chrom-LinX Auto 1200/700		2312-1221
Chrom-LinX Auto 450/700S		2345-1211
Chrom-LinX Auto 600/700S		2360-1211
Chrom-LinX Auto 800/700S	10μm	2380-1211
Chrom-LinX Auto 1000/700S		2310-1211
Chrom-LinX Auto 1200/700S		2312-1211

Accessories	Specification	Product code
Braided silicone tubing	3/8 inch, ID 9.5mm, TC25 chuck, 2m in length	2611-1121
Braided silicone tubing	3/4 inch, ID 19mm, TC25 chuck, 4m in length	2611-1221
Braided silicone tubing	1 inch, ID 25.4mm, TC50 chuck, 4m in length	2611-1321
Braided silicone tubing	3/8 inch, 316L material, four-way, one-pass, TC25	2611-1341
Braided silicone tubing	1.5 inch, ID 38.1mm, TC50 chuck, 4m in length	2611-1442
Cross valve	1/2 inch, 316L material, four-way, one-pass, TC25	2621-1121
Cross valve	1 inch, 316L material, four-way, one-pass, TC50	2621-1152
Diaphragm valve	DN15, chuck end, ID 9.4mm, 316L material, TC25	2622-2011
Diaphragm valve	DN20, chuck end, ID 15.75mm, 316L material, TC25	2622-2031
Diaphragm valve	DN25, chuck end, ID 22.1mm, 316L material, TC50	2622-2042
Diaphragm valve	DN40, chuck end, ID 22.1mm, 316L material, TC50	2622-2052
Chuck	TC25, 304 stainless steel	2631-1010
Chuck	TC50, 304 stainless steel	2631-1020
Gasket	3/8 inch, TC25, EPDM	2632-3110
Gasket	1/2 inch, TC25, EPDM	2632-3210
Gasket	3/4 inch, TC25, EPDM	2632-3310
Gasket	1 inch, TC50, EPDM	2632-3420
Gasket	1.5 inch, TC50, EPDM	2632-3520
Upper column head o-ring	EPDM(Chrom-LinX Auto 450)	2345-4110
Upper column head o-ring	EPDM(Chrom-LinX Auto 1000)	2310-4110
Upper column head scraper	UPE(Chrom-LinX Auto 450)	2345-4220
Upper column head scraper	UPE(Chrom-LinX Auto 1000)	2310-4220
Bottom column head o-ring	EPDM(Chrom-LinX Auto 450)	2345-4310
Bottom column head o-ring	EPDM(Chrom-LinX Auto 1000)	2310-4310
Upper sieve plate	316L stainless steel, 10μm	2345-2131
Upper sieve plate	316L stainless steel, 20μm	2345-2132
Upper sieve plate	316L stainless steel, 10μm	2310-2131
Upper sieve plate	316L stainless steel, 20μm	2310-2132
Bottom sieve plate	316L stainless steel, 10μm	2345-2231
Bottom sieve plate	316L stainless steel, 20μm	2345-2232
Bottom sieve plate	316L stainless steel, 10μm	2310-2231
Bottom sieve plate	316L stainless steel, 20μm	2310-2232

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Want to know more about BioLink bioprocessing products? Feel free to contact BioLink now!

Email

info@biolink.com

Phone

+86-400-058-9000

ADDRESS

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Chrom-LinX® Automated Chromatography Column

Overview of Chrom-LinX® Automated Chromatography Column

Features of Chrom-LinX® Automated Chromatography Column

Specifications of Chrom-LinX® Automated Chromatography Column

Material of Chrom-LinX® Automated Chromatography Column

Packing-LinX® Column Packing Workstation

Ordering Information of Chrom-LinX® Automated Chromatography Column