Chrom-LinX^® Auto Automated Chromatography Column

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Overview of Chrom-LinX^® Auto Automated Chromatography Column

Chrom-LinX^® Auto Automated Chromatography Column works in a low-pressure and axial compression mode as a standardized equipment with ID of 450, 600, 800, 1000, 1200 mm and column tube height of 700 mm (1000 mm customizable), making itself suitable for the manufacturing of various types and scales of bioproducts.

The exhaust structure of the columns has been carefully designed and tested to allow for easy exhaust and cleanliness of the column head, reducing cleaning and maintenance steps. The design of the column head distribution plate ensures uniform distribution of liquid flow. The packing process is controlled by software in the column packing workstation, which enables intelligent loading and unloading, as well as automated packing, dismantling and maintenance operations through programming, ensuring the stability and reproducibility of packing. A pre-homogenized resin is pumped into the column through the inlet at the column bottom. The column head is driven upwards by a servo moto r, and after pumping in a sufficient amount of homogenate, the column head moves downwards to pack the resin. The speed of the column head can be set by software, and the accuracy of the movement distance can reach 1mm. The height of the column bed can be precisely controlled so that the resin forms a uniform and stable bed structure within the column.

Features of Chrom-LinX^® Auto Automated Chromatography Column

• Column tube is acrylic structure, clear vision, column bed position visible.

• Sanitary design, in line with GMP requirements.

• Material safety, in line with the regulatory requirements.

• Scientific design, no clean dead corner.

• Can be used for a variety of packing.

• Specifications of inner diameter: 300, 450, 600, 800, 1000, 1200 mm.

• Height range: 550 and 570 mm.

• Screen aperture: 10μm and 20μm are optional.

Specifications of Chrom-LinX^® Auto Automated Chromatography Column

Material of Chrom-LinX^® Auto Automated Chromatography Column

Chrom- LinX^® Auto Automated Chromatography Columns are made of materials suitable for biopharmaceutica l pro- duction. The structural materials conform to ASME biological processing equipment standards, and the wetted polymer mate ria ls and e lastic materia ls meet the requirements of USP<88> in vivo biological reactivity test and FDA 21 CFR Part 177. All materials contain no ingredients of animal origin and comply with the regulations in EMA/410/01 2nd edition. The parts used are traceable back to the product batch. Wetted parts can withstand most chemical reagents commonly used in chromatography, such as buffers or organic reagents for adsorption, elution, washing and preservation, as well as disinfectant solutions.

Packing-LinX^® Column Packing Workstation

The Packing- LinX^® Column Loading Workstation enables 21 CFR Part 11 compliant packing operations. Chromatography columns are operated via the touch screen of the workstation. The workstation supports functions including venting, filling, disassembly, and maintenance besides corresponding programs, which can be selected and set by the operator as needed. During the packing process, the equipment will stop automatically when the set compression factor or height is reached, or the operator can stop it manually at any time.

Ordering Information of Chrom-LinX^® Auto Automated Chromatography Column