CytoLinX BR Single-use Stirred Tank Bioreactor

Name: CytoLinX BR Single-use Stirred Tank Bioreactor
Brand: Bio-Link

CytoLinX BR single-use stirred tank bioreactor is developed based on DCS architecture, and its underlying logic is built by Siemens PCS 7, so as to cover the automatic control requirements from R&D to production, from a single unit to the whole upstream plant, and its automatic control logic conforms to ISA 88 control standards. The disposable bioreactor for cell culture can cover 50, 200, 500, 1000, 2000 L scale, its software design in accordance with GMP and 21 CFR Part 11 requirements. At the same time, in order to facilitate the use of users, CytoLinX BR software interface design is minimal, all functions at a glance, and can greatly meet the needs of customers. The automatic control system can meet the functions of real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control, and has stable pH, DO, temperature control performance.

For more efficient mixing, Bio-Link has introduced a new bottom dial design that can maintain a high linear KLa. And provide microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions, to meet the needs of a variety of cells tricky culture.

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More Functions BRC BRU Features Specifications Video Contact us

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More About CytoLinX BR Single-use Stirred Tank Bioreactor

The supporting single-use consumables can be selected according to the needs of customers, such as micro-bubble, medium-bubble, big-bubble and other ventilation combinations. The perfusion bioreactor has a stable linear kLa, and the cultivation effect is comparable to most reactors on the market.

Functions of CytoLinX ™ BR Single-use Stirred Tank Bioreactor

CytoLinX ™ BR Single-use Stirred Tank Bioreactor comes standard with working volumes of 50 L, 200 L, 500 L, 1000 L, and 2000 L. Including a vessel, a controller and a temperature control unit (TCU), it is used for culturing mammalian cells, in-sect cells, and other low shear-rate needed cells. 2000l Single Use Bioreactor

Figure 1 CytoLinX ™ BR single-use bioreactor (50–2000 L)

CytoLinX ™ BRC (The Controller of Disposable Bioreactors)

CLK-BRC's control hardware is built with SIEMENS PCS 7 and hardware control units, which meets the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits ISA 88 control standard and 21 CFR Part 11.

Hardware control units are all built with high-end brands parts to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.

One CLX-BRC controller can easily to control different types of Bio-Link single-use bioreactor system. We also could use CLX-BRC to control several bioreactors at the same time.

Single Use Stirred Tank Bioreactor

Figure 2 Main operating interface of CytoLinX ™ BRC

CytoLinX ™ BRU (The Unit of Disposable Bioreactors)

CLX-BRU operates with bottom-drive agitators. It has a patented sparge design that supports flexible combinations of micro, medium and large bubble sizes, helping to optimize the culture process, enhance the cell density, and maintain the cell viability.

For the operation of CytoLinX ™ BRU, two types (air-cooled and water-cooled) of temperature control units (TCU) are available to meet customers’ specific needs in different applications.

Features of CytoLinX BR Single-use Stirred Tank Bioreactor

User-friendly interface for "plug-in" controller
The Single-use Stirred Tank Bioreactor can realize the function of "plug and play" of "1 control cabinet to control multiple tanks"
Adopt stable DCS control system, in line with ISA 88 control standard
The configuration is flexible and can be partially customized according to user's needs
21 CFR Part 11 is in software designed scope
Main parts are using high-end brands
The sparge provides micro, medium and large bubble size options to meet various processing needs
Provide perfect FAT, SAT, IQOQ files and services

Specifications of CytoLinX BR Single-use Stirred Bioreactor

Item	Options		CLX BR-50	CLX BR-200	CLX BR-500		CLX BR-1000	CLX BR-2000
System parameters
Working volume (L)			20– 50	40–200	100– 500		200– 1000	400–2000
Height to diameter ratio (H/D)			2.5:1 or 1.5:1	1.5:1	1.5:1		1.5:1	1.5:1
Bag lifting device and installation ladder							√	√
Accessory parameters
pH conventional elec- trodes	Single-use/Arc elec-		1-3	2-3	2-3		2-3	2-3
DO optical conventional electrodes	trodes		1-3	2-3	2-3		2-3	2-3
PAT tools	pCO2 /cell density		0-2	0-2	0-2		0-2	0-2
Gas mass flow controller (MFC)	Optional gas and range		4-6	4-6	4-6		4-6	4-6
Integrated pump unit	Series 1, 3, and 5		2-4	2-4	2-4		2-4	2-4
Reserved port for external pump unit	Series 5, 6, and 7		0-4	0-4	0-4		0-4	0-4
Weighing module			1	1	1		1	1
Tail gas heating jacket	Optional size		2-4	2-4	2-4		2-4	2-4
Reserved port for external weighing
Temperature control unit (TCU)	Air-cooled or wa- ter-cooled		5 kW	5 kW	5 kW		10 kW	10 kW
Control unit
Hardware	SIEMENS PCS 7 (DCS, compliant with ISA 88)
Display	19'' touch screen display, mouse and keyboard conforming to appropriate protection class, and built-in UPS
Compliance	Compliant with 21 CFR PART 11
Consumables
Sparger	Micro, medium, and large bubble size options available	Micro + large or medium + large bubble size design in the standard product
Tubing	Customizable tubing length	The tubing length in the standard in requirements				product is sufficient for post-installation weld-
Tail gas filter	Optional size	4.5''		6.7''		6.7''	10''	10''

CytoLinX BR Single-use Stirred Tank Bioreactor Video （50L-2000L Single-use Bioreactor）

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Want to know more about Bio-Link bioprocessing products? Feel free to contact Bio-Link now!

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info@biolink.com

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+86-400-058-9000

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01 Dec 2023