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CytoLinX BR Single-use Stirred Tank Bioreactor

CytoLinX BR single-use stirred tank bioreactor is developed based on DCS architecture, and its underlying logic is built by Siemens PCS 7, so as to cover the automatic control requirements from R&D to production, from a single unit to the whole upstream plant, and its automatic control logic conforms to ISA 88 control standards. The disposable bioreactor for cell culture can cover 50, 200, 500, 1000, 2000 L scale, its software design in accordance with GMP and 21 CFR Part 11 requirements. At the same time, in order to facilitate the use of users, CytoLinX BR software interface design is minimal, all functions at a glance, and can greatly meet the needs of customers. The automatic control system can meet the functions of real-time data acquisition and recording, PID automatic control, online monitoring, multi-parameter cascade control, and has stable pH, DO, temperature control performance.


For more efficient mixing, Bio-Link has introduced a new bottom dial design that can maintain a high linear KLa. And provide microbubble, medium bubble, large bubble and a variety of combinations of consumable solutions, to meet the needs of a variety of cells tricky culture.

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Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.


More About CytoLinX BR Single-use Stirred Tank Bioreactor

The supporting single-use consumables can be selected according to the needs of customers, such as micro-bubble, medium-bubble, big-bubble and other ventilation combinations. The perfusion bioreactor has a stable linear kLa, and the cultivation effect is comparable to most reactors on the market.

Functions of CytoLinX ™ BR Single-use Stirred Tank Bioreactor

CytoLinX ™ BR Single-use Stirred Tank Bioreactor comes standard with working volumes of 50 L, 200 L, 500 L, 1000 L, and 2000 L. Including a vessel, a controller and a temperature control unit (TCU), it is used for culturing mammalian cells, in-sect cells, and other low shear-rate needed cells.2000l Single Use Bioreactor

Figure 1 CytoLinX ™ BR single-use bioreactor (50–2000 L)


CytoLinX ™ BRC (The Controller of Disposable Bioreactors)

CLK-BRC's control hardware is built with SIEMENS PCS 7 and hardware control units, which meets the automation requirements from research to production, as well as from single system to enterprise-wide solution. The software fits ISA 88 control standard and 21 CFR Part 11.


Hardware control units are all built with high-end brands parts to ensure robust and reliable performance. Also, a choice of PAT tools can be configured flexibly to meet different customer needs and applications.


One CLX-BRC controller can easily to control different types of Bio-Link single-use bioreactor system. We also could use CLX-BRC to control several bioreactors at the same time.


Single Use Stirred Tank Bioreactor

Figure 2 Main operating interface of CytoLinX ™ BRC


CytoLinX ™ BRU (The Unit of Disposable Bioreactors)

CLX-BRU operates with bottom-drive agitators. It has a patented sparge design that supports flexible combinations of micro, medium and large bubble sizes, helping to optimize the culture process, enhance the cell density, and maintain the cell viability.


For the operation of CytoLinX ™ BRU, two types (air-cooled and water-cooled) of temperature control units (TCU) are available to meet customers’ specific needs in different applications.


Features of CytoLinX BR Single-use Stirred Tank Bioreactor

  • User-friendly interface for "plug-in" controller

  • The Single-use Stirred Tank Bioreactor can realize the function of "plug and play" of "1 control cabinet to control multiple tanks"

  • Adopt stable DCS control system, in line with ISA 88 control standard

  • The configuration is flexible and can be partially customized according to user's needs

  • 21 CFR Part 11 is in software designed scope

  • Main parts are using high-end brands

  • The sparge provides micro, medium and large bubble size options to meet various processing needs

  • Provide perfect FAT, SAT, IQOQ files and services


Specifications of CytoLinX BR Single-use Stirred Bioreactor

Item

OptionsCLX BR-50CLX BR-200CLX BR-500CLX BR-1000CLX BR-2000

System parameters

Working volume (L)

20– 50

40–200

100– 500

200– 1000

400–2000

Height to diameter ratio (H/D)

2.5:1 or 1.5:1

1.5:1

1.5:1

1.5:1

1.5:1

Bag lifting device and installation ladder




Accessory parameters

pH conventional elec- trodes

Single-use/Arc elec-

1-3

2-3

2-3

2-3

2-3

DO optical conventional electrodes

trodes

1-3

2-3

2-3

2-3

2-3

PAT tools

pCO2 /cell density

0-2

0-2

0-2

0-2

0-2

Gas mass flow controller

(MFC)

Optional gas and range

4-6

4-6

4-6

4-6

4-6

Integrated pump unit

Series 1, 3, and 5

2-4

2-4

2-4

2-4

2-4

Reserved port for  external pump unit

Series 5, 6, and 7

0-4

0-4

0-4

0-4

0-4

Weighing module


1

1

1

1

1

Tail gas heating jacket

Optional size

2-4

2-4

2-4

2-4

2-4

Reserved port for

external weighing

Temperature control unit

(TCU)

Air-cooled or wa-

ter-cooled

5 kW

5 kW

5 kW

10 kW

10 kW

Control unit

Hardware

SIEMENS PCS 7 (DCS, compliant with ISA 88)

Display

19'' touch screen display, mouse and keyboard conforming to appropriate protection class, and built-in UPS

Compliance

Compliant with 21 CFR PART 11

Consumables

Sparger

Micro, medium, and large bubble size   options available

Micro + large or medium + large bubble size design in the standard product

Tubing

Customizable tubing length

The tubing length in the standard in requirements

product is sufficient for post-installation weld-

Tail gas filter

Optional size

4.5''

6.7''

6.7''

10''

10''


CytoLinX BR Single-use Stirred Tank Bioreactor Video (50L-2000L Single-use Bioreactor)

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