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Chrom-LinX® Auto TH Chromatography Column

The Chrom-LinX® Auto TH Chromatography Column is designed for downstream purification in biopharmaceutical manufacturing. It enables intelligent packing through automated control software (Packing-LinX® Column Packing Station), reducing manual steps required for conventional columns. Column packing with the Slurry-LinX® series slurry tank allows most of the process to remain in a closed environment, minimizing the exposure and contamination risks of the chromatography resin and slurry. 


Chrom-LinX® Auto TH columns are engineered to deliver excellent performance with a wide range of resins. They are compatible with the ChromaX® Chromatography Resins, and perform particularly well with high rigidity, high flow rate resins, such as Chromstar® FF and MaXtar®. The Packing-LinX® workstation presets the packing method for each resin type, which simplifies the packing process and improves production efficiency.

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Specifications Material Workstation Ordering Information Contact us

Chrom-LinX® Auto TH columns are low-pressure, axial compression chromatography columns which are suitable for process development and manufacturing of biopharmaceutical products. They are standardized equipment with ID of 450, 600, 800, 1000, 1200, 1400 and 1600 mm and column tube height of 700 mm (1000 mm customizable). The columns feature an optimized venting design for efficient air removal and easy cleaning of adapter. The distribution system design ensures uniform flow through the column bed. The packing process is controlled by the workstation software to achieve intelligent packing, unpacking, installation, dismantling and maintenance procedures, ensuring the stability and reproducibility of packing. The resin slurry is introduced via a bottom inlet and the adapter is driven upwards by a servo motor. After introducing a sufficient amount of slurry, the adapter moves down to pack the resin. The movement speed is controlled by software, with accuracy up to 1 mm, allowing precise control of bed height to form a uniform and consolidated bed.


Specifications of Chrom-LinX® Auto TH Chromatography Column

Column Specifications


Column Inner Diameter (mm)4506008001000120014001600
Column Tube Height  (cm)700
Maximum Operating Pressure0.3 MPa (3 bar or 43.5 psi)
Operating Temperature (° C)2-40
Bed Support (μm)10/20


Material of Chrom-LinX® Auto TH Chromatography Column

The construction materials of Chrom-LinX® Auto TH are suitable for biopharmaceutical manufacturing and conform to the ASME Bioprocessing Equipment Standard. Wetted polymeric materials and elastomers meet the requirements of USP <88> Biological Reactivity Tests, In Vivo and FDA 21 CFR Part 177. All materials are free from animal-derived ingredients and comply with the regulations in EMA/410/01 (Rev. 2). All parts used are traceable to the product batch. Wetted parts can withstand most chemical reagents commonly used in chromatography, such as buffers or organic reagents for adsorption, elution, washing and storage, as well as disinfectant solutions.


Component 

Description

Column tube

Acrylic

Seals

EPDM+UPE

Distributor

PP

Top plate

316L stainless steel

Adapter

2205 stainless steel

Bed support net

316L stainless steel

Tubing/Fittings

316L stainless steel

Resin valve body

PP

Stand

304 stainless steel

Caster

Nylon + polyurethane


Packing-LinX® Column Packing Station

The Packing-LinX® Column Packing Station enables 21 CFR Part 11 compliant packing operations. The touch screen interface offers an overview of the venting, packing, unpacking, and maintenance procedures. The packing process will stop automatically when the set compression factor or bed height is reached, or the operator can stop it manually at any time.


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Ordering Information of Chrom-LinX® Auto TH Chromatography Column

Chromatography ColumnBed SupportCat. No.
Chrom-LinX® Auto 450/700 TH20 μm2845-1221
Chrom-LinX® Auto 600/700 TH2860-1221
Chrom-LinX® Auto 800/700 TH2880-1221
Chrom-LinX® Auto 1000/700 TH2810-1221
Chrom-LinX® Auto 1200/700 TH2812-1221
Chrom-LinX® Auto 450/700S TH10 μm2845-1221
Chrom-LinX® Auto 600/700S TH2860-1221
Chrom-LinX® Auto 800/700S TH2880-1221
Chrom-LinX® Auto 1000/700S TH2810-1221
Chrom-LinX® Auto 1200/700S TH2812-1221
Braided silicone tubing1/2 inch, ID 12.7 mm, TC25 chuck, 2 m in length2611-1221
Braided silicone tubing3/4 inch, ID 19 mm, TC25 chuck, 2 m in length2611-1321
Braided silicone tubing3/4 inch, ID 19 mm, TC25 chuck, 4 m in length2611-1341
Braided silicone tubing1 inch, ID 25.4 mm, TC50 chuck, 4 m in length2611-1442
Braided silicone tubing1.5 inch, ID 38.1 mm, TC50 chuck, 4 m in length2611-1542
Cross valve3/8 inch, 316 L stainless steel, four-way, one-pass, TC252621-1121
Cross valve1/2 inch, 316 L stainless steel, four-way, one-pass, TC252621-1131
Cross valve3/4 inch, 316 L stainless steel, four-way, one-pass, TC252621-1141
Cross valve1 inch, 316 L stainless steel, four-way, one-pass, TC502621-1152
Manual diaphragm valveDN10, chuck end, ID 7.75 mm, 316 L stainless steel, TC252622-2011
Manual diaphragm valveDN15, chuck end, ID 9.4 mm, 316 L stainless steel, TC252622-2021
Manual diaphragm valveDN20, chuck end, ID 15.75 mm, 316 L stainless steel, TC252622-2031
Manual diaphragm valveDN25, chuck end, ID 22.1 mm, 316 L stainless steel, TC502622-2042
Manual diaphragm valveDN40, chuck end, ID 22.1 mm, 316 L stainless steel, TC502622-2052
ClampTC25, 304 stainless steel2631-1010
ClampTC50, 304 stainless steel2631-1020
Gasket3/8 inch, TC25, PTFE2632-4110
Gasket1/2 inch, TC25, EPDM2632-3210
Gasket3/4 inch, TC25, EPDM2632-3310
Gasket1 inch, TC50, EPDM2632-3420
Gasket1.5 inch, TC50, EPDM2632-3520

**Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.

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