The depth filtration holder is designed to remove large cell particles in the preparation of biological products, such as cell clarification (in bioreactor rooms) or intermediate product filtration (in purification rooms). The depth filtration system consists of a power unit, a cassette holder, a detection unit, and an automatic control unit. In this document, we will focus on the cassette holder.
The depth filter holder is used to hold deep filtration cassettes of a given area. Under the action of a power pump, the feed liquid passes through the cassettes, which intercepts the solid particles in the liquid for clarification. The depth filtration holder is designed to meet the needs for laboratory research and development, pilot-scale production, and large-scale production. The depth filtration holder is suitable for a variety of primary and secondary clarification and filtration applications, including mammalian cell culture media, yeast culture media, E. coli lysate, E. coli renaturation buffer, pharmaceutical intermediates, culture media, plasma proteins, and serum.
The vertical P3C series fixture design is particularly suitable for biopharmaceutical process. The depth filtration holder is very simple, safe, and intuitive to use, occupying little space.
Compatible with prevalent round deep filtration cassettes on the market;
The position of the top turnplate and the distance of the guide rod can be adjusted according to the number of cassettes, so as to properly hold different numbers of cassettes;
The ergonomic design allows for loading, filtering and disassembling in the vertical direction;
Resistant to the disinfection by acid, alkali, organic solvents, and other disinfectants, meeting the requirements for CIP and cleaning validation;
Easy to install and use and ready for production, allowing assembly, operation and disassembly steps to be performed independently by the user;
Carefully designed, highly performing, technically innovative, energy efficient, safe and reliable, and easy to maintain;
Made of SS 316L stainless steel, without compromising the cleanliness of the pharmaceutical production environment;
Smooth surface for easy cleaning;
Surface polished Ra < 1.2 μm, polished part in contact with the product Ra < 0.5 μm;
Material certificates are available;
Adopts cGMP, EU GMP and FDA certified food grade lubricants;
Complete set of accessories;
Equipped with 4 lockable wheels;
It works with a deflector to offer a variety of working modes, such as down-in & up-out, up-in & down-out, down-in & down-out, series filtration and parallel filtration, for enhanced flexibility in different processing applications;
Smaller residual volume for higher recovery rates.
Product Code | DH-CHN-05H | DH-CHN-10H |
Dimensions (mm) | 1150 × 974 × 1682 | 1150 × 974 × 2207 |
Weight of Bin (kg) | 192 | 240 |
Cassette loading capacity (in the case of PALL cassettes) | Small disc cassette 0.5 m2/0.25 m2: | Small disc cassette 0.5 m2/0.25 m2: |
1–10 pcs | 1-20 pcs | |
Medium disc cassette 1.0 m2/0.5 m2: | Medium disc cassette 1.0 m2/0.5 m2: | |
1–7 pcs | 1-14 pcs | |
Large disc cassette 2.0 m2/1.0 m2: | Large disc cassette 2.0 m2/1.0 m2: | |
1–5 pcs | 1-10 pcs | |
Material of rack | SS 304 | |
Substance solution contact part | SS 316L | |
Surface finish | Ra < 0.5 μm |
GAD drawing
Quality certificate
Instructions for use
List of spare parts
Product Code | Item Description | Compatible cassettes |
DH-CHN-05H | Depth Filter Holder | 1–5 pieces of PALL/3M/cobetter round membranes |
DH-CHN-10H | Depth Filter Holder | 1–7 pieces of PALL/3M/cobetter round membranes |
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