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chrom linx manual compression chromatography column 1
chrom linx manual compression chromatography column 1
chrom linx manual compression chromatography column

Chrom-LinX® Manual Compression Chromatography Column

Chrom-LinX® manual chromatography columns are the ideal choice for purification applications. Specifically designed to meet the needs for the chromatography process development in biopharmaceuticals, these columns can be packed with various commonly used media available in the market, including "soft gels"1 like dextran-based agaros, as well as "hard gels" like poly (styrene divinylbenzene) (PS-DVB)2 and hydroxyapatite3. They provide an ideal column platform with high versatility, adaptability and stability. Utilizing the widely adopted rotation compression sealing method in the industry, the simplified design of Chrom-LinX® columns significantly enhances the user experience, and improve the efficiency and success of media packing. 


The Chrom-LinX® series columns are designed to optimize the user experience by offering a comprehensive range of optional accessories and spare parts including tubing, valves, consumables, etc. Such a ecosystem empowers users to confidently tackle chromatography processes without any apprehensions about purification challenges.




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Features Material Specifications Contact us

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.


Features of Chrom-LinX® Manual Compression Chromatography Column

  • The SCHOTT borosilicate glass column tubing, with precise column tubing inner diameter and smooth coaxial circumference, ensures meticulous and efficient separation and purification.

  • The upper and lower sieves of the column are made of USP <88> Class material, and based on the customized plastic sealing process of BioLink. The column is endowed with low flow pressure difference, high liquid dispersion ability, and excellent distribution performance.

  • Sealing components are made of EPDM material in accordance with USP <88> Class, providing excellent sealing performance with a minimal dead cavity volume.

  • All parts in contact with the liquid are made of pharmaceutical-grade high-quality stainless steel, offering excellent rigidity and corrosion resistance.

  • The tubing connection is based on sanitary Tri-Clamp quick fittings, and the sanitary design of the whole flow path ensures the cleanliness of the column.

  • Optimized screw lifting and O-ring sealing handles for operating sensations make the operation effortless.

  • The bottom is designed with a side outlet interface for easy connection to valve tubing connector and other components. The micro-slope design ensures efficient liquid drainage, easy cleaning, and no dead corners.

  • Adaptive column packing reservoirs with a variety of specifications are available to facilitate packing of higher column beds.


Material of Chrom-LinX® Manual Compression Chromatography Column

Parts

Material

Column tubingSCHOTT borosilicate glass

Metal parts in contact with fluids

ASTM 316L/2205 stainless steel

Sealing components

EPDM

O-ring knobs

PEEK

Distribution plates*

PP (Polypropylene)

Support screen**

PP (Polypropylene)

Sieve (10μm/23μm)

10μm sieve made of PA (nylon)

23μm sieve made of PP (polypropylene)

Support

304 stainless steel

Caster

PU (Polyurethane)

*Chrom-LinX 300/X chromatography columns are equipped with distribution plate, with no support screen.

**Chrom-LinX 100/X, 140/X, 200/X chromatography columns are equipped with support screens, with no distribution plate.



Specifications of Chrom-LinX® Manual Compression Chromatography Column

Product Code and Specification Table

Product codeProduct nameColumn tube material

Inner 

diameter

of

column 

tubing

(mm)

Pore size of column tubing

(mm) 

Height

of 

column 

tubing

(mm)

Height

of 

column 

bed

(mm)

Volume 

of 

column 

bed

(L)		Maximum 
operating 
pressure
(bar)
2410-1111Chrom-LinX 100/500Glass1001050050-3500.4-2.85
2410-1112Chrom-LinX 100/750Glass10010750200-5801.6-4.55
2410-1113Chrom-LinX 100/950Glass10010950400-7503.9-5.85
2414-1111Chrom-LinX 140/500Glass1401050050-3500.8-5.35
2214-1112Chrom-LinX 140/750Glass14010750200-5803.0-8.95
2214-1113Chrom-LinX 140/950Glass14010950400-7507.7-11.55
2420-1111Chrom-LinX 200/500Glass2001050050-3501.6-114.4
2420-1112Chrom-LinX 200/750Glass20010750200-5806.28-18.24.4
2420-1113Chrom-LinX 200/950Glass20010950400-75015.7-224.4
2430-1111Chrom-LinX 300/500Glass2961050050-3503.5-24.74.4
2430-1112Chrom-LinX 300/750Glass29610750200-58014.2-40.94.4
2430-1133Chrom-LinX 300/950Glass29610950400-75028.3-52.94.4


Common Accessories

Product codeNameSpecificationQuantity
2621-1111Cross valve1/4", 316L material, four-way, one-pass, TC252
2611-1721Platinum vulcanized braided silicone hose
1/4", ID 4.76mm, TC25 clamp connector, 316L material 2m in length2
2632-3610Gasket
1/4", TC25, chuck, EPDM6
2631-1010ChuckTC25, 304 stainless steel6
2621-1131Cross valve1/2", 316L material, four-way, one-pass, TC252
2611-1221Platinum vulcanized braided silicone hose1/2", ID 7.9mm, TC25 clamp connector, 316 material, 2m in length2
2632-3210Gasket1/2",  TC25, EPDM6
2631-1010ChuckTC25, 304 stainless steel6
2622-2011Manual straight joint diaphragm valve1/4", valve body316L material, EPDM diaphragm+PTFE, TC25
2622-2021Manual straight joint diaphragm valve3/8", valve body316L material, EPDM diaphragm+PTFE, TC25
2622-2031Manual straight joint diaphragm valve1/2", valve body316L material, EPDM diaphragm+PTFE, TC25
2621-1211Cross valve1/4", 316L material, four-way, two-pass, TC25
2621-1221Cross valve

3/8", 316L material, four-way, two-pass, TC25


2621-1231Cross valve

1/2", 316L material, four-way, two-pass, TC25


2410-6111Column packing reservoir

Diameter 100mm, height 500mm, column tube (made of glass)


2414-6111Column packing reservoir

Diameter 140mm, height 500mm, column tube (made of glass)


2420-6111Column packing reservoir

Diameter 200mm, height 500mm, column tube (made of glass)


2430-6111Column packing reservoir

Diameter 300mm, height 500mm, column tube (made of glass)


2651-1111Stirring rodsPR, chassis diameter 80mm, rod 1m in length
2651-1121Stirring rodsPR, chassis diameter 140mm, rod 1m in length
2651-1131Stirring rodsPR, chassis diameter 200mm, rod 1m in length





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