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CytoLinX^® RW 10-200L Single-use Rocking Bioreactor

Name: CytoLinX ® RW 10-200L Single-use Rocking Bioreactor
Brand: Bio-Link
Price: 100 USD

Boost Productivity with Single-Use Wave Bioreactors

CytoLinX® RW 10-200 L single-use rocking systems are available in a variety of models, including 10 L, 20 L, and 50 L for 0.3–25 L culture volumes, and 100 L and 200 L for 10–100 L culture volumes. During the culture process, introduce air/oxygen (filtered by a sterile filter) into the culture bag to obtain a certain space. Place the culture bag on the rocking platform to rock, and the medium will form a rocking movement in the culture bag. Such design enables good oxygen supply and cell mixing, as well as a mild cell culture microenvironment with low shear force and high dissolved oxygen.

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CytoLinX® RW 10-200 L single-use rocking systems improve the cell status by protecting them from damage due to the shear force and bubbling at the impeller ends in traditional mixing vessels. As a result, the undulating fluid level of the medium is constantly in contact with the oxygen introduced into the culture bag, providing sufficient dissolved oxygen for cell growth. Cell density and product yield can be increased by adjusting the shaking speed and angle, and by introducing a certain ratio of air/oxygen mixture into the bag.

Featuring a flexible culture volume range, easy operation, precise control, and easy process scale-up, the single-use wave bioreactors are suitable for various cell culture conditions, including scientific research, research and development, in-process seed culture, and new therapies, such as cell therapy. Single-use wave bioreactors are transforming modern bioprocessing with their unparalleled efficiency. The disposable bioreactor for cell culture significantly reduces shear-related cell damage, thereby maintaining higher cell viability and stable growth rates.

Functions of CytoLinX^® RW Single-use Rocking Bioreactor

Functions of CytoLinX WB Single-Use Rocking Bioreactor

Figure 1 CytoLinX^® WB single-use rocking bioreactor

BioLink's CytoLinX® RW is controlled by Siemens PLC. The advanced PID feedback control and the optical compensation of fiber optic electrodes further improve the stability and reliability of cell culture. With precise detection and feedback regulation, the cell culture process is monitored from all aspects together with data acquisition, data analysis, data comparison, and report printing are also available. The software is user-friendly, easy to operate, and compliant with 21 CFR Part 11.

Wave Bioreactor System

Figure 2 CytoLinX^® RW Single-use Rocking Bioreactor user interface

Features of CytoLinX^® RW Single-use Rocking Bioreactor

The software interface is easy to operate, stable to run, and supports audit trail
Allows convenient replacement and quick installation of trays and culture bags
Supports perfusion and automatic calibration of pump flow rate for accurate feeding and harvesting
Ventilation, pH/DO, and perfusion modules are optional, depending on process requirements
Supports DO-associated N2 reverse regulation for a wide range of applications, which helps to control cell state more accurately for cell therapy customers
With variable frequency speed regulation, the shaking mode is adjustable to further reduce the shear force and achieve a mild cell culture process
Precise measurement of gases with mass flow controllers (MFC)
The whole device is equipped with monitoring alarm and protection functions for automatic fault sensing, diagnosis, and alerts
Several types of consumables are available, including the basic type, the pH & DO electrode type, and the perfusion type
Rich application and operation support, and high-speed response speed
Fast delivery and flexible customization

Specifications of CytoLinX^® RW Single-use Rocking Bioreactor

Name	Description	Range
Hardware	SIEMENS PLC
Display	13.3'' tablet computer; PC optional
Compliance	Compliant with 21 CFR PART 11
Rocking bioreactor 0.3 –25 L
Tray	Available in 10 L, 20 L, and 50 L	0.3 – 25 L (working volume)
Mixing	Speed	2 – 40 RPM
Mixing	Angle	2 – 14°
Temperature control	Electric heating	RT-40 °C
Gas flow control	Air mass flow controller × 1	0 – 1 Lpm
	O2 mass flow controller × 1	0 – 0.5 Lpm
	CO2 mass flow controller × 1	0 – 0.2 Lpm
	N2 mass flow controller × 1 (optional)	0 – 0.5 Lpm
Pumps	Series 1 variable speed pump × 2 – 6 (optional)	0 – 300 RPM
Sensors	Pt 100 temperature sensor × 3	2 – 45 °C
	pH electrode transmitter and fiber × 1	6 – 8 pH
	DO electrode transmitter and fiber × 1	0 – 100 %
	Weight sensor × 4	0 – 30 kg
	Pressure sensor × 1	0 – 1 Psi

Standard Configuration for CytoLinX® RW 10-50 L Single-use Rocking System

Accessory	Unit	Range	Accuracy
Load cell	KG	0-30	±0.05
Rotation speed	RPM	2-40	±1
Angle	°	2-14	±0.5
pH	NA	4.5-8.5	±0.05
DO	%	0-200	±5.0
Temperature	℃	Room temperature -60	±0.2
Bag pressure	mbar	0-69	±1% FS
Exhaust heating	℃	45-60	±5
Peristaltic pump	RPM	0-300	±10% FS
MFC Air	SLPM	0.01%-100%	±0.8% FS
MFC O2	SLPM	0.01%-100%	±0.8% FS
MFC CO2	SLPM	0.01%-100%	±0.8% FS

Standard Configuration for CytoLinX® RW 100-200 L Single-use Rocking System

Accessory	Unit	Range	Accuracy
Load cell	KG	0-150	±0.5
Rotation speed	RPM	2-40	±1
Angle	°	2-14	±0.5
pH	NA	4.5-8.5	±0.05
DO	%	0-200	±5.0
Temperature	℃	Room temperature -60	±0.2
Bag pressure	mbar	0-69	±1% FS
Exhaust heating	℃	45-60	±5
Peristaltic pump	RPM	0-300	±10% FS
MFC Air	SLPM	0.01%-100%	±0.8% FS
MFC O2	SLPM	0.01%-100%	±0.8% FS
MFC CO2	SLPM	0.01%-100%	±0.8% FS

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.

Ordering Information for CytoLinX^® RW Single-use Rocking Bioreactor

Ordering Information for CytoLinX® RW 10-50 L Single-use Rocking System

Cat. No.	Name	Configuration						Cuture Volume (L)
Cat. No.	Name	Rocking Base	Central Control Unit	Process Control Unit	Pump Unit	Exhaust Heating Sleeve	Tray Lid	Cuture Volume (L)
CRW050L A-001	CytoLinX® RW 50 L Single-use Rocking System (pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *1	CRWEHU050L *1	CRWTL050L *1	1-25 L
CRW020L A-001	CytoLinX® RW 20 L Single-use Rocking System (pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *1	CRWEHU050L *1	CRWTL020L *1	0.3-10 L
CRW010L A-001	CytoLinX® RW 10 L Single-use Rocking System (pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *1	CRWEHU050L *1	CRWTL010L *1	0.3-5 L
CRW050L B-001	CytoLinX® RW 50 L Single-use Rocking System (pH&DO&perfusion)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *2	CRWEHU050L *1	CRWTL050L *1	1-25 L
CRW020L B-001	CytoLinX® RW 20 L Single-use Rocking System (pH&DO&perfusion)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *2	CRWEHU050L *1	CRWTL020L *1	0.3-10 L
CRW010L B-001	CytoLinX® RW 10 L Single-use Rocking System (pH&DO&perfusion)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LA -001*1	CRWPGU050L *2	CRWEHU050L *1	CRWTL010L *1	0.3-5 L
CRW050L C-001	CytoLinX® RW 50 L Single-use Rocking System (without pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LB -001*1	X	CRWEHU050L *1	CRWTL050L *1	1-25 L
CRW020L C-001	CytoLinX® RW 20 L Single-use Rocking System (without pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LB -001*1	X	CRWEHU050L *1	CRWTL020L *1	0.3-10 L
CRW010L C-001	CytoLinX® RW 10 L Single-use Rocking System (without pH&DO)	CRWRBU050L *1	CRWCCU050LA *1	CRWPCU050LB -001*1	X	CRWEHU050L *1	CRWTL010L *1	0.3-5 L
CRW050L D-001	CytoLinX® RW 50 L Single-use Rocking System (one-way) rocking&temperature)	CRWRBU050L *1	CRWCCU050LB *1	X	X	CRWEHU050L *1	CRWTL050L *1	1-25 L
CRW020L D-001	CytoLinX® RW 20 L Single-use Rocking System (one-way) rocking&temperature)	CRWRBU050L *1	CRWCCU050LB *1	X	X	CRWEHU050L *1	CRWTL020L *1	0.3-10 L
CRW010L D-001	CytoLinX® RW 10 L Single-use Rocking System (one-way) rocking&temperature)	CRWRBU050L *1	CRWCCU050LB *1	X	X	CRWEHU050L *1	CRWTL010L *1	0.3-5 L
• Product sequence: 001 is for standard configuration; other numbers are for customized products.

Ordering Information for CytoLinX® RW 100-200 L Single-use Rocking System

Cat. No.	Name	Configuration				Cuture Volume(L)
Cat. No.	Name	Central Control Unit	Rocking Base	Exhaust Heating	Tray Lid	Cuture Volume(L)
CRW100L-001	CytoLinX® RW 100L Single-use Rocking System	CRWCCU200L-001*1	CRWRBU200L*1	CRWEHU200L* 2	CRWTL100L*1	5-50L
CRW200L-001	CytoLinX® RW 200L Single-use Rocking System	CRWCCU200L-001*1	CRWRBU200L*1	CRWEHU200L* 2	CRWTL200L*1	10-100L

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Want to know more about BioLink bioprocessing products? Feel free to contact BioLink now!

Email

info@biolink.com

Phone

0086-400-058-9000

ADDRESS

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CytoLinX® RW 10-200L Single-use Rocking Bioreactor

Functions of CytoLinX® RW Single-use Rocking Bioreactor

Features of CytoLinX® RW Single-use Rocking Bioreactor

Specifications of CytoLinX® RW Single-use Rocking Bioreactor

Ordering Information for CytoLinX® RW Single-use Rocking Bioreactor