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Hydroxyapatite BARONHAP^® Type I&II Multimodal Chromatography Resin

Name: Hydroxyapatite BARONHAP ® Type I&II Multimodal Chromatography Resin
Brand: Bio-Link
Price: 100 USD

Hydroxyapatite [Ca₁₀(PO₄)₆(OH)₂] is an inorganic pure-phase chromatography resin, which consists of spheres calcined at high temperatures. Its crystal structure is the same as that of hydroxyapatite in bone, with stable spherical structure and uniform particle sizes. Hydroxyapatite can interact with biomolecules in multiple modes to realize two separation mechanisms simultaneously: cation exchange and calcium metal affinity. The cation exchange mainly depends on the negatively charged phosphate groups on hydroxyapatite. Also, carboxyl clusters and phosphorus clusters on biomolecules can form stronger bonds with calcium on hydroxyapatite through metal affinity. Due to these unique separation mechanisms, hydroxyapatite has become an indispensable chromatography resin in today's extremely demanding downstream processes and plays an important role in the fields of biopharmaceuticals such as antibodies, vaccines (bacterial polysaccharides, pneumonia polysaccharides, and viruses), nucleic acids, enzymes, and recombinant proteins.

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Features of Hydroxyapatite BARONHAP^® Type I&II Multimodal Chromatography Resin

Inorganic pure-phase multimodal chromatography resin with a stable structure.
Supporting multiple separation modes, including cation exchange, calcium affinity, and separation by hydroxyl groups.

Specifications of Hydroxyapatite BARONHAP^® Type I&II Multimodal Chromatography Resin

Hydroxyapatite prepacked column

Product Name	ID×Bed Height (mm)	Mean particle size (μm)	Max. back pressure (MPa)	Recommended flow Rate (mL/min)	Pack SIze	Cat. No.
Chrom-Trap® BARONHAP^® type I, 40 μm 1 mL	7.7/25	40	3	1	1 × 1 mL	2010-1121
Chrom-Screen BARONHAP^® type I, 40 μm 4.7 mL	7.7/100	40	3	1 – 4.7	1 × 4.7 mL	2010-1122
Chrom-Trap® BARONHAP^® type I, 40 μm 5 mL	16/25	40	3	1 – 5	1 × 5 mL	2010-1123
Chrom-Trap® BARONHAP^® type II, 40 μm 1 mL	7.7/25	40	4	1	1 × 1 mL	2011-1121
Chrom-Screen BARONHAP^® type II, 40 μm 4.7 mL	7.7/100	40	4	1 – 4.7	1 × 4.7 mL	2011-1122
Chrom-Trap® BARONHAP^® type II, 40 μm 5 mL	16/25	40	4	1 – 5	1 × 5 mL	2011-1123

Hydroxyapatite chromatography resin

Product Name	Max. back pressure (MPa)	Max. flow Rate (cm/h)	Mean particle size (μm)	Pack Size	Cat. No
BARONHAP^® type I	3	400	40 μm	10 g	1110-1121
				25 g	1110-1122
				100 g	1110-1123
				1 kg	1110-1124
				5 kg	1110-1125
BARONHAP^® type II	4	400	40 μm	10 g	1111-1121
				25 g	1111-11222
				100 g	1111-1123
				1 kg	1111-1124
				5 kg	1111-1125

**Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.

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Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resin

Features of Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resin

Specifications of Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resin